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BRCA2 |
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The genes, called BRCA1 and BRCA2, normally encode proteins that suppress rampant cell growth. The oncogenes c-myc, c-met, k-ras and the neoplastic progression protein-3 (Npn3) were also increased 2- to 3-fold in arsenic-induced HCC and nontumorous, normal liver from arsenic exposed mice, while the tumor suppressors BRCA1 and BRCA2 decreased 30-50%. Researchers already know that mutations on two genes, called the BRCA1 and BRCA2, significantly increase a woman's risk of the disease. |
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