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BUB1 |
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Cluster 1 included genes that are associated with proliferation (K167, cyclin A, BUB1, cyclin B1, and thymidine kinase), whereas clusters 7 and 9 included genes that are associated with cell survival (bcl-XL, defender against cell death 1 [BFL1], BAK, BAG1, and MCL1) and with plasma cell differentiation (XBP1, STAT3, IRF4, and ribosomal proteins). The investigators do not have direct proof that mutations in the human BUB1 lead to aneuploidy, although they do have evidence that the mutant gene enables human cells to proceed with aspects of cell division after being treated with drugs that disrupt spindle assembly. Human BUBR1 was first identified as an interacting protein of the kinetochore motor protein CENP-E (6) and also as a protein that contains regions homologous to yeast Mad3 and BUB1 (9). |
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