BUB1Budding Uninhibited by Benzimidazoles 1
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These 11 genes were Gbx2, KI67, CCNB1, BUB1, KNTC2, USP22, HCFC1, RNF2, ANK3, FGFR2, and CES1.
The investigators do not have direct proof that mutations in the human BUB1 lead to aneuploidy, although they do have evidence that the mutant gene enables human cells to proceed with aspects of cell division after being treated with drugs that disrupt spindle assembly.
The researchers have found a second human gene related to BUB1, and they are examining whether it -- or human versions of the other yeast genes that cause chromosomal instability -- is mutated in cancers.