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BH1BCL-2 (B-Cell Lymphoma-2) Homology 1
BH1Basal Cell Hyperplasia 1 (gastroenterology)
References in periodicals archive ?
In vitro studies have shown that EBV latent membrane protein 1 (LMP1) induces bcl-2 expression in lymphoid cells (6).
Pan-Anti-Apoptotic BCL-2 Family Inhibitor, Obatoclax, Activates Autophagic Cell Death Pathway and Has Potent Cytotoxicity in Infant and Pediatric MLL-Rearranged Leukemias (2647: Sunday, December 7, 2008)
ABT-737 targets proteins from the Bcl-2 family, which are found at high levels in up to 70 per cent of breast cancers," Dr Lindeman said.
By targeting a key survival mechanism of cancer cells, Abbott scientists identified ABT-263 as a potent inhibitor of Bcl-2 family proteins.
The level of Bcl-2 and Bax protein was measured by flow cytometry as described with minor modifications (Liu and Zhu, 1999).
Bcl-2 activity upregulates in many types of cancer and correlates with cancer cell resistance to a wide spectrum of chemotherapy agents.
An oral drug, ABT-199/GDC-0199 was designed to exclusively mimic the binding of this "BH3" structural element exclusively to the BCL-2 protein, hence the drug class designation of "BH3-mimetic".
Immunochemistry showed CD45, BCL-2, BCL-6, CD10, CD20, and CD79a positivity and CD30, MUM1, EBER, and CD34 negativity.
Cells are pressured toward apoptosis by expression of pro-apoptotic BCL-2 proteins.
Up-Regulation of Bcl-2 in microvascular endothelial cells enhances intratumoral angiogenesis and accelerates tumor growth.
Beyond those two compounds, scientists at the two companies will use their expertise to conduct additional follow-on research in the area of Bcl-2 family protein antagonists and VEGFR-targeted (vascular endothelial growth factor receptor) kinase inhibitors.