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These include members of the Bcl-2 protein family, which have both proapoptotic and antiapoptotic activity (Bcl-2 is antiapoptotic), and other inhibitors (Figure 1). While there is tumor individuality, the neoplastic cells usually show a B cell phenotype (CD19, CD20, CD22, CD79a) with coexpression of CD10 and CD43; they also express bcl-2 and bcl-6 and demonstrate light-chain (kappa or lambda) restriction. We examined the effects of cadmium on the bcl-2 family of proteins--bcl-2, bax, bad, and bcl-xS/L--in cadmium-induced cytotoxicity. |
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