A BeLPT drawn that day had a stimulation index of 2.
A BeLPT drawn 2 days prior was normal (stimulation index of 1.
BeLPT at that time was normal (stimulation index of 1.
We now know that cellular (rather than humoral) immunity is responsible for its manifestations, that increased susceptibility is conferred through major histocompatibility complex class II genetic variants, and that sensitization to beryllium can be detected via specific lymphocytic proliferative responses measured by the BeLPT (Amicosante and Fontenot 2006; Kreiss et al.
The abnormal BeLPT results at the time of acute illness indicate the presence of a cell-mediated immune response to beryllium concurrent with the acute reaction to beryllium.
In descending order for the other combination of tests, the predictive values for CBD were scarring on the radiograph in all zones with negative BeLPT (75%), positive BeLPT (48.
Because the PPD reaction is similar to BeLPT, this suggests that a decreased immune response to beryllium may occur in individuals with a lower body burden of beryllium (i.
Only 56 of the 110 (51%) individuals who screened positive by radiograph or BeLPT elected to have a bronchoscopy.
However, there were individuals who had CBD with an abnormal chest radiograph, involving all or just the upper lobes, and negative BeLPT (Table 6).
Predictive power of having unrecognized CBD documented by bronchoscopy based on results of BeLPT and chest radiograph.
Using flow cytometry and the BeLPT
, we demonstrated that the murine response to topical beryllium occurs in the LN draining the site of chemical application, the auricular LN in our study, and that T cells are activated and released into the peripheral blood.