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The NRC, in their examination of the Faroe Islands cohort study, the study on which they place greatest reliance, stated that "[b]ecause these calculations necessitate extrapolating to estimate the mean response at zero exposure level," logarithmic models "lead to lower estimates of the Benchmark Dose (BMD) than linear or K-power models" (NRC 2000, p. The proposed method should provide better estimates for the NOEL and confidence limits for benchmark dose levels. Using benchmark dose (BMD) methodology, the results for each tissue were also compared for both the individual laboratory and the pooled data from all laboratories using the same test substance and, where applicable, the same stimulating TP dose. |
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