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Statistical analysis began with a two way ANOVA using experiment as one factor, and dose as the second factor for length comparsions, followed by Bonferroni t-test multiple comparisons Tox Tools, a software for dose-response modeling, benchmark dose estimation and risk assessment was used to calculate LC50 (lethal concentration to induce 50% mortality) and EC50 (effective concentration to induce 50% malformation) with standard errors (ToxTools, 2001). The NRC, in their examination of the Faroe Islands cohort study, the study on which they place greatest reliance, stated that "[b]ecause these calculations necessitate extrapolating to estimate the mean response at zero exposure level," logarithmic models "lead to lower estimates of the Benchmark Dose (BMD) than linear or K-power models" (NRC 2000, p. Even though one study found no adverse health effects from maternal mercury exposure to fetuses, the NRC focused on another study that did find an effect in order to determine the benchmark dose at 85 parts per billion. |
Benchmark Dose |
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