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BPAR
(redirected from Biopsy-Proven Acute Rejection)

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AcronymDefinition
BPARBiopsy-Proven Acute Rejection
BPARBlack-Pigmented Anaerobic Rods (dentistry)


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Novartis says the results of Phase III clinical trial (n=729) showed a two-dose regimen of Simulect, used concomitantly with cyclosporine for microemulsion and corticosteroids, proportionately reduced the incidence of biopsy-proven acute rejection by nearly one-third (31% incidence with Simulect; 45% with placebo) during the first six months post transplant.
A composite endpoint consisting of death, graft failure, biopsy-proven acute rejection or loss to follow up within 12 months after randomization will be the primary outcome measure.
The incidence of biopsy-proven acute rejection greater than or equal to ISHLT grade 3A at month 12 was 30.
 
 
 
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