Decreased ratio of HPCs (B) and HSCs (C) in iron overload (Fe) bone marrow mononuclear cells (BMMNCs) reversed by deferasirox (DFX) or N-acetyl-L-cysteine (NAC).
Using an antioxidant such as N-acetyl-Lcysteine (NAC) to decrease ROS levels partially attenuates bone marrow mononuclear cell (BMMNC) and umbilical cord-derived MSC injury in vitro (14,31).
Results from the in vitro culture revealed that VP-16 upregulated TRAIL expression in the bone marrow mononuclear cells of patients with acute leukemia, but the binding of VP-16 to IFN did not enhance TRAIL expression as compared with VP-16 alone (p>0.
Treatment with VP-16 and the combination of VP-16 with 1FN upregulated TRAIL expression in the bone marrow mononuclear cells of patients with acute leukemia at 24 h after the treatment, as compared with that in the control group (p<0.
Implantation of bone marrow mononuclear cells
into ischemic myocardium enhances collateral perfusion and regional function via side supply of angioblasts, angiogenic ligands, and cytokines.
The team of Brazilian researchers has evaluated the safety and efficacy of a surgical procedure involving multiple injections into the heart (intramyocardial) of a bone marrow mononuclear cells
(BMMCs) formulation derived from the patient (autologous) called "Refractory Angina Cell Therapy (ReACT)".
Those conditions that cannot be successfully treated with cells derived from autologous bone marrow mononuclear cells
(BMMNCs), are also likely to represent strong future opportunities in the stem cell market.
Both used autologous bone marrow mononuclear cells
in randomized treatment of patients at different intervals following a heart attack.
The Phase 1/2 double-blind study included 21 subjects randomly selected to receive an injection of either ALD-301 or unsorted cells from their own bone marrow (autologous bone marrow mononuclear cells
, or ABMMNC).
November 18, 2013 -- Scientists here conducted a study to examine the safety of transcndocardial stem cell injection (TESI) with autologous mesenchymal stem cells and bone marrow mononuclear cells
in patients with ischemic cardiomyopathy.
The Phase 1/2 double-blind study included 21 subjects randomly selected to receive an injection of cither ALD-301 or unsorted cells from their own bone marrow (autologous bone marrow mononuclear cells
, or ABMMNC).
Citation: "Autologous Bone Marrow Mononuclear Cell
Therapy for Severe Traumatic Brain Injury in Children;" Charles S Cox, James E Baumgartner, Matthew T Harting, Laura L Worth, Peter A Walker, Shinil K Shah, Linda Ewing-Cobbs, Khader M Hasan, Mary-Clare Day, Dean Lee, Fernando Jimenez, Adrian Gee.