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Human coronavirus OC43 is believed to have been derived from bovine coronavirus (4). 0% amino acid (aa) conservation in the spike (S) protein with bovine coronavirus within group 2 coronaviruses, which provides strong evidence for a recent host-species shift (2). In addition, the potential to infect other species has been described for bovine coronavirus and is suspected to have caused the SARS outbreak (10,11). |
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