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Irrefutable evidence does confirm that the nonhuman retroviruses avian leukosis virus (ALV), bovine leukemia virus (BLV), feline leukemia virus (FeLV), and murine leukemia virus (MuLV) induce lymphoproliferative disease in birds, cattle, cats, and mice, respectively; all are usually associated with T-cell leukemias. Similar to the membrane proteins of bovine leukemia virus gp30, (26) Epstein-Barr virus LMP2A, (27) and Kaposi sarcoma virus K1, (28) MMTV's ENV gene is a membrane protein that contains immunoreceptor tyrosine-based activation motifs (ITAM) domains. caused by the bovine leukemia virus [BLV]) was also found among infected cattle. |
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