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METHODS: The present study investigates global alterations in the proteome of bronchoalveolar lavage fluid taken from rats 1, 7, or 30 days after exposure to 5, 35, or 50 mg/kg of animal weight of DEPs. 1,3,13) Most authors do not recommend lung biopsy; bronchoalveolar lavage fluid analysis, while not a prerequisite, may be helpful in the diagnosis. A variable region amplified from a bronchoalveolar lavage fluid specimen can generate either 2 bands (simple pattern) or >2 bands (complex pattern). |
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