One patient treated for syphilis with Bicillin C-R subsequently had neurosyphilis diagnosed.
Editorial Note: Inadvertent use of Bicillin C-R for treatment of syphilis was documented in several STD programs during 1993-1998 (4).
Therefore, whether treatment failures that occurred among those treated with Bicillin C-R represent an excess over what would be expected had they been treated with Bicillin L-A cannot be determined without additional data.
FDA worked with CDC and King Pharmaceuticals to design and implement changes to the product labeling, including more easily visible carton-color changes to distinguish L-A and C-R formulations, and the warning, "not for the treatment of syphilis," printed directly on syringes and cartons of Bicillin C-R.
For more than 50 years, physicians have utilized Bicillin([R]) C-R as a safe and effective treatment for a variety of susceptible upper respiratory tract infections, moderate to severe pneumonia and skin and soft-tissue bacterial infections," stated Linda Wase, M.
Please note: Bicillin([R]) C-R and Bicillin([R]) L-A are NOT identical.
Bicillin([R]) C-R is contraindicated in individuals with hypersensitivity to any penicillin-type antibiotic or to procaine.
For more information about Bicillin([R]) C-R, visit www.
To determine the frequency of Bicillin C-R use in STD clinics nationwide and to educate STD program managers about the possible confusion between Bicillin C-R and Bicillin L-A, CDC surveyed 65 STD program areas during January-February 1999 about unintentional Bicillin C-R use from 1993 through 1998.
Among the 55 state/city program areas that responded to the survey, 31(56%) were unaware of the possible confusion between Bicillin C-R and Bicillin L-A; 24 (46%) program areas routinely ordered Bicillin L-A by telephone.
Editorial Note: The inadvertent use of Bicillin C-R in county A's STD clinic disrupted routine public health functions and incurred substantial monetary costs to the clinic and unnecessary discomfort to patients.
In addition to Maryland, five program areas reported unintentional use of Bicillin C-R from 1993 through 1998.