C3GCyanidin 3-Glucoside
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Tart cherry anthocyanins mixture and purified C3G were produced in M.
5] cells/ml of adipose stem cells were pretreated with varying doses of lipitor, tart cherry extract, tart cherry anthocyanins mixture and C3G for 4h prior to co-stimulation of these cells with the same doses of these reagents in the presence of LPS for an additional 18h.
C3G has anti-inflammatory properties in human adipocytes (Tsuda et al.
C3G is one of the major bioactive anthocyanins of tart cherry (Chandra et al.
Additionally, C3G protects retinal cells from harmful oxidation that is triggered by light and reduces the age-associated accumulation of a fluorescent pigment called A2E that interferes with normal function of the retina.
Although not a fruit, black soybean hull is rich in anthocyanins, and notably, in C3G (cyanidin-3-O-beta-D-glucoside), as discussed in the section on blackberries.
And C3G is the most common of the anthocyanins found in dark fruits--which come from plants that thrive best in direct sunlight, where free radicals are generated in abundance.
It's no accident, then, that C3G has recently been shown to provide animal and human tissues optimal defense from free radical attack, both by preventing their formation and by scavenging those already formed.
What has researchers so interested in C3G, however, is that it also protects from the "downstream" consequences of free radicals at the genetic level.
Here, the hypotheses were tested that Mirtoselect, an anthocyanin mixture from bilberry, or isolated cyanidin-3-glucoside (C3G), the most abundant anthocyanin in diet, interfere with intestinal adenoma formation in the Apc(Min) mouse, a genetic model of human familial adenomatous polyposis, and that consumption of C3G or Mirtoselect generates measurable levels of anthocyanins in the murine biophase.
Oral pretreatment with C3G significantly inhibited the formation of ethanol-induced gastric lesions and the elevation of the lipid peroxide level.
Black Soybean Hull: This is another extremely rich source of the anthocyanin C3G.