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CA4P

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AcronymDefinition
CA4PCombretastatin A-4 Phosphate


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This was a randomized open-label study of intravenous CA4P administered at 45 or 63 mg/m2 followed by paclitaxel and carboplatin in 13 patients.
The authors hypothesized that because adhesion of leukemic cells to vascular cells may confer resistance to chemotherapeutic agents, treatment with CA4P would promote leukemic cell death by disrupting leukemic cell cytoskeletal stability and interfering with vascular cell interactions.
Anderson Cancer Center in Houston, TX and colleagues report that both triple-drug combinations incorporating CA4P showed positive results, as determined by tumor volume and weight assessments, in mouse xenograft models of ATC utilizing two human ATC cell lines.
 
 
 
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