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CADASILCerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy
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sup][3] Clinical manifestations of CADASIL include migraine with aura, subcortical ischemic events, mood disturbances, apathy, and cognitive impairment.
Although still in mice, this suggests that activating Notch3 antibodies could be developed as therapeutics to reduce disease progression in CADASIL patients.
In the two-plus years since Nelson had that discussion with Marie-Germaine Bousser, neurology chief at Hospital Lariboisiere in Paris, France, he and an international research team studying CADASIL and other small artery diseases are uncovering what occurs in the brains of people born with the genetic mutation of a protein known as Notch3.
Three patients with CADASIL belonging to the same family and attending a specialist neurological center as outpatients were invited to participate in the study (patients A, B and C in Table 1).
Ischaemic cerebral vascular disease caused by vasculitis, antiphospholipid syndrome, CADASIL, leukoaraisosis, or MS should be kept in mind in the differential diagnosis of cerebral WMLs.
CADASIL imitating multiple sclerosis: the importance of MRI markers.
Clinical severity in CADASIL related to ultrastructural damage in white matter: In vivo study with diffusion tensor MRI.
CADASIL is an early-onset form of subcortical ischemic vascular dementia that is unlikely to overlap with Alzheimer's disease, making it a condition well suited for testing the effects of donepezil on cognitive functioning, said Dr.
In other cases, however, such as the taupathies, mitochondriopathies, CADASIL, X-Linked Adrenoleukodystrophy, etc.
These include the discovery of a monogenic form of vascular dementia, CADASIL, and identification of the causative gene as Notch 3.