The Role of CagA
in the Gastric Biology of Helicobacter pylori.
pylori strain, such as babA2, cagA
, vacA, and iceA1 have been identified and involved in pathogenesis of infection.
Based on the presence or absence of cagA
, a gene encoding the CagA
protein, in its bacterial genome, H.
pylori strains that are CagA
positive, there is an increase in the potential of an early abortion (possibly through the increase of inflammatory cytokins release).
In our study was used from cloned cagA
gene which had been prepared in our previous work.
The inhibitory effect of soluble saActRIIB-l-ECD and saActRIIB-2-ECD on luciferase activity in the CAGA
assay indicated that both act as inhibitors of MSTN and activin signaling.
El mecanismo de adhesion, combinado con los efectos de las proteinas VacA y CagA
, contribuye con la inflamacion y el dano de la celula gastrica, que le proporciona al patogeno el aumento de la cantidad de nutrientes en el lumen gastrico y evita que la bacteria sea arrastrada por los movimientos peristalticos del estomago [77,85].
Specific serum immunoglobulin G to H pylori and CagA
in healthy children and adults (south-east of Iran).
This adhesion is essential for ensuring the prolonged persistence of the bacterium in the stomach and for the injection of CagA
and other proteins into epithelial cells, using a type IV secretion system.
De acuerdo al grado de patogenicidad se han definido 2 tipos de cepas, tipo I cagA
(+) y tipo II cagA
Blaser's previous studies have confirmed the bacterium's link to stomach cancer and elucidated genes associated with its virulence, particularly a gene called cagA
We then focused on gastric cancer to determine whether cagA
positivity was associated with an increased risk for that disease.