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CAPRIE

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AcronymDefinition
CAPRIEClopidogrel vs Aspirin in Patients at Risk of Ischemic Events


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The CAPRIE trial (42) studied 19,000 patients with stroke, MI, or peripheral vascular disease and showed only a modest, 8.
In the CURE trial, patients with unstable angina (UA) and non-ST segment elevation myocardial infarction (NSTEMI) receiving Plavix([R])with aspirin were followed for up to one year, and in the CAPRIE trial, patients with recent MI, recent ischemic stroke, or established peripheral artery disease receiving Plavix([R])alone were followed for up to three years.
However, Prasugrel has to go through an intensive Phase III clinical program to translate the better platelet inhibition seen in Phase I studies to improved clinical outcomes in terms of reducing MI and other CAD instances and death compared to Clopidogrel - essentially an expensive and time consuming study similar to CAPRIE study done for establishing Clopidogrel's marginal superiority over Aspirin.
 
 
 
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