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CARISACombination Assessment of Ranolazine in Stable Angina
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CARISA randomized to ranolazine or placebo 823 chronic stable angina patients who remained symptomatic on amlodipme, atenolol, or diltiazem.
In CARISA, 823 patients with chronic angina symptoms despite being on diltiazem, atenolol, or amlodipine were randomized to either ranolazine or placebo in addition to their background therapy.
These data provide important additional information on the potential underlying mechanism which may be responsible for significant HbA1c reductions without associated hypoglycemia in both the CARISA and MERLIN-TIMI 36 studies," said Luiz Belardinelli, M.
In CARISA (Combination Assessment of Ranolazine in Stable Angina), Ranexa reduced HbA1c levels by an average of up to 0.