Also found in: Dictionary, Thesaurus, Medical, Encyclopedia, Wikipedia.
Related to CASPASE: Caspase 3, Caspase 9
CASPASECysteine Aspartic Acid Specific Protease
CASPASECleaving At Cysteine-Aspartic Residues
References in periodicals archive ?
In general, two distinct signaling pathways of caspase activation during apoptosis have been described.
As it can be seen in diagram 1, enzyme protein level of caspase 3 indicated increase in gastric cancer tissue of both groups after three curses of chemotherapy with Cz's-Platin.
Amer explains that these findings represent a paradigm shift in caspase research.
The extrinsic pathway is triggered when death ligands bind to their respective cell surface death receptors through recruitment of FAS-associated death domain (FADD) protein, procaspase-8 through the formation of a complex that induces cell death and activation of the caspases (caspase-8 and caspase-10).
Using two other wilting coral species, the researchers found that adding a chemical that inhibits caspase activity could stop the corals from committing suicide.
Salvesen, 2004, "The Protein Structures That Shape Caspase Activity, Specificity, Activation And Inhibition", Biochem .
The latter were initially assumed to result from caspase inhibition, but further studies showed that these drugs prevent initiation of the intrinsic apoptotic pathway by stabilizing the mitochondrial membrane potential.
Caspase activation was significantly elevated in patients with definitive NASH, with median cytokeratin-18 levels of 767 U/L, compared with 202 U/L in patients with simple steatosis.
Biochemical data are consistent with the hypothesis that CV1013 inhibited primarily caspase 8, thereby blocking the initial intracellular signal that would be expected to lead to apoptotic cell death and liver failure.
Because caspase activation is a very early event in apoptosis, monitoring it could speed clinicians' ability to determine whether, how and when these new drugs work, said Bogyo.
To demonstrate the relation between caspase activation and apoptosis induction by rosamultic acid in SGC-7901 cancer cells, we evaluated the activities of caspase-3, -9 and -8 using the colorimetric assay.
Full browser ?