CB11Cyanogen Bromide Peptide 11
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GARLIC (Pureed, Dehydrated and Fresh Peeled) Porter Foods Co, Ltd, 24 High Street, Newport, Saffron Walden, Essex CB11 3PQ.
GINGER (Unsweetened Pureed, Diced, Sliced and Sweetened Pulp) Porter Foods Co, Ltd, 24 High Street, Newport, Saffron Walden, Essex CB11 3PQ.
Immunohistochemical studies for p53 (clone DO7, 1:100; Dako, Carpinteria, California), cyclin D1 (clone H-295, 1:150; Santa Cruz, Santa Cruz, California), and HER2/neu (clone CB11,1:200; Novocastra, Newcastle, United Kingdom) were performed as described previously.
These include Herceptest, a rabbit polyclonal (DAKOCytomation, Copenhagen, Denmark), and Pathway (Ventana, Medical Systems, Tucson, AZ), which uses the Mab CB11.
A new rabbit monoclonal antibody (4B5) for the immunohistochemical (IHC) determination of the HER2 status in breastcancer: comparison with CB11, fluorescence in situ hybridization (FISH), and interlaboratory reproducibility.
2 1:50 (prediluted) p63 4A4 1:500 S100 Polyclonal 1:300 Smooth muscle actin 1A4 1:50 Calponin CALP 1:50 Smooth muscle myosin heavy chain SMMS1 1:800 Antimitochondrial antibody 113-1 1:50 p53 DO7 1:100 Ki-67 ki-55 1:25 Androgen receptor AR411 1:100 HER2/neu CB11 1:200 Gross cystic disease fluid 23A3 1:25 protein-15 Table 2.
LPA Niphan Systems Ltd Tudor Works Debden Road Saffron Walden Essex CB11 4AN Fax: 0044 (0) 1799 512828 Tel: 0044 (0) 1799 512800 sales@lpa-nipham.
25) The early trials of trastuzumab in metastatic breast cancer enrolled patients after central testing using an immunohistochemistry (IHC) assay with the anti-HER2 antibodies 4D5 (the parent antibody of trastuzumab) and CB11 on formalin-fixed, paraffin-embedded tissue, and this clinical trials assay identified staining patterns for HER2 as negative (0 and 1+) or positive (2+ and 3+).
Bartlett et al (77) observed a concordance rate between FISH amplified and IHC 2+/3+ of 67% with the HercepTest and 83% with the CB11 antibody.