CBPI was calculated as (number mononucleate cells + 2x number binucleate cells + 3x number poiynucleate cells) + total number of cells.
None of the variables included in the initial model (maternal age, birth weight, child sex, maternal BMI, GA, delivery type, preterm status, smoking, and supplement intake) were significant predictors of MNBN and CBPI among the 173 children with complete data for all potential predictors (Table 3).
As for all births combined, no variables significantly predicted MNBN frequency or CBPI (Table 3).
However, we found a significant positive association between maternal CBPI and child's CBPI (data not shown).
Mothers who delivered by cesarean section had significantly higher CBPI values compared with those who delivered naturally, and higher prepregnancy BMI also was associated with higher CBPI values.
Unique to this study is the evaluation of MNBN, MNMONO, CBPI, and GA of the newborns, whereas a weakness of the study was the limited data on folate concentration in erythrocytes and plasma vitamin B12 concentration.
The data from this study demonstrates that viral proteins such as SERP-1 and CBPI in combination with immunosuppressants can effectively diminish chronic rejection in rat kidney transplants, which suggests the importance of this approach to modifying a patient's immune response," said Robert Zhong, M.
The study investigated the effect of SERP-1 and CBPI in combination with the immunosuppressant cyclosporine.
With this study, we continue to add to promising early pre-clinical data for SERP-1 and CBPI, our lead products for the treatment of transplant rejection.
The title of the study is "Viral Proteins SERP-1 and CBPI Prevent Chronic Rejection in Rat Renal Allografts".