CC16Clara Cell Secretory Protein 16
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In animals, he's found, strains producing the most CC16 suffer the least damage from ozone.
CC16 concentrations in the blood increased during exercise.
After exercise, the animals exhibited a comparable release of CC16 into blood and a similarly inappropriate movement of a different protein from blood into the lungs.
We did not find consistent associations of air pollution with changes in IL6, IL8, TNF[alpha], CRP, or CC16 (Table 2).
Further research is needed to confirm the results, establish the clinical relevance of short-term serum CC16 changes, and evaluate the long-term health impacts.
The aim of this study was to explore short-term respiratory changes in healthy adults after swimming in an indoor chlorinated swimming pool by measuring lung function and a wide range of biomarkers that may reflect different mechanisms of effect, specifically, airway inflammation (FeNO, eight cytokines, and a growth factor in EBC), oxidative stress (8-isoprostane in FBC), and epithelial lung permeability (SP-D and CC16 in serum), taking into account both exposure to DBPs and physical exercise.
Studies have shown a positive association between ozone exposure and increased concentrations of CC16 in blood serum, leading researchers to suggest that ozone exposure damages the lung epithelium, causing it to "leak" proteins such as CC16.
Lagerkvist and colleagues report that children who regularly visited indoor swimming pools actually showed decreased concentrations of CC16 both before and after sessions of exercise outdoors in ambient levels of ozone.
CC16 in serum has been proposed as a noninvasive and sensitive marker of lung epithelial injury.
CC16 has antioxidant properties, and the levels in serum increase when lung epithelium permeability is adversely affected by air pollutants or other lung toxicants (Broeckaert et al.
The assay of CC16 in the serum represents a new sensitive noninvasive test allowing the detection of early effects of ambient [O.
The serum concentration of CC16 is a new sensitive marker to detect an increased permeability of the epithelial barrier, which is one of the earliest signs of lung injury induced by air pollutants, including [O.