The expression of 15 cytokines genes (ADIPOQ, BMP2K, CCL3
, CXCL13, IL-16, IL-28B, IL-34, SPP1, TGFB1, TNFAIP2, TNFAIP3, TNFAIP8, TNFAIP8L1, TNFSF11, and TNFSF13B) was significantly upregulated by 2.
9) observed upregulation of mRNA in CD34-derived DCs for IL1[beta], IL6, IL8, CCL2, CCL3
, CCL4, and CCL3L1 by sensitizers.
We also evaluated chemokine genes that have shown altered expression in septic patients: IL8 (interleukin 8), CXCL10 [chemokine (C-X-C motif) ligand 10], PF4 (platelet factor 4), CCL3
[chemokine (C-C motif) ligand 3], and CXCL1 [chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)].
In-vitro secretion of the chemokines CCL3
and CCL4 produced by CLL cells was inhibited by CAL-101.
Addition of GPE + PR inhibited the expression of most of the abovementioned genes including 1L1[beta], ILla, IL6, IL8, C3 and CCL3