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Moreover, idiopathic PAH frequently reveals inflammatory infiltrates (macrophages, lymphocytes, and dendritic cells) in the range of plexiform lesions with local expression of chemokines CCL2 (MCP-1 [monocyte chemoattractant protein-1]), CCL5 (RANTES [regulated upon activation, normal T-cell expressed and secreted]), and CX3CL1 (fractalkine) seen (42-45). 3 CXCL10 ([dagger]), N = 232-1,019 26,319 16,156 CCL2 ([dagger]), N = 18-152 445 257 CXCL9 ([dagger]), N = 37-463 1,138 1,605 CCL5, N = 10,349-46,704 24,745 60,671 * N, normal range; IFN, interferon; IL, interleukin; UD, undetected; TNF, tumor necrosis factor. Other chemokines analyzed included the eosinophil chemoattractant CCL11 (eotaxin), as well as CCL3 (macrophage inflammatory protein [MIP]-1a) and CCL5 (RANTES [regulated upon activation, normal T-cell expressed and secreted]), which are all bound and scavenged by D6 from supernatants of cultured cells (17). |
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