CCN2

AcronymDefinition
CCN2Connective Tissue Growth Factor (also known as CTGF)
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Step 1: Analysis of the need for changes to the integration of the national domain of the Trans-European systems with the Community domain resulting from the introduction of CCN2 platform;
Step 2: Create Specification requirements necessary changes in the integration of the national domain of the Trans-European Systems with Community domain resulting from the introduction of CCN2 platform.
Urinary CCN2 (CTGF) as a possible predictor of diabetic nephropathy: preliminary report.
Giaccia and his collaborators found that human pancreatic cancer cells expressing high levels of CCN2 grew robustly when injected under the skin of mice.
Cancer cells expressing high levels of CCN2 formed tumors that grew more rapidly and metastasized more aggressively than did those expressing lower levels, and the mice died sooner than others injected with cancer cells expressing less CCN2.
The researchers wondered if CCN2 played a role in keeping tumor cells alive in hypoxic conditions.
Many other cellular conditions can also kick-start CCN2 expression, including the presence of CCN2 itself.
A phase-1 clinical trial testing the safety of an antibody that binds CCN2 and blocks its activity in a small number of patients began in December at Stanford and Dartmouth-Hitchcock Medical Center.