Genotyping of XPG, XPC, CCNH and MMS19L was performed in a 384-well plate format on the MassARRAY(R) platform.
However, the response to chemo-therapy of osteosarcoma by XPG, XPC, CCNH and MMS19L has not been studied.
Genotyping of XPG, XPC, CCNH and MMS19L was performed in a 384-well plate format on the MassARRAY(R) platform (Sequenom(R), San Diego, CA, USA), which combines polymerase chain reaction (PCR) and matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry technologies.
Association between response to chemotherapy and XPG, XPC, CCNH and MMS19L genotypes was analyzed by logistic regression analysis with odds ratio (OR).
78) Among genes overexpressed in MM, several were involved in cell cycle checkpoints, such as CDK1/CDC2 (cyclin-dependent kinase 1), CDC6 (cell division cycle 6, a regulator of replication), CDKN2C (cyclin-dependent kinase inhibitor 2C, p18), CCNH
(cyclin H), CCNB1 (cyclin B1, controlling the cell cycle at the G2/ M transition), CHEK1 (Chk1 is required for checkpoint-mediated cell cycle arrest in response to DNA damage), and FOXM1 (forkhead transcription factor, a regulator of gene expression in the G2 phase).
With the strength of these two organizations working together, SPB+G and CCNH clients can anticipate new and more comprehensive services to meet their needs through Sheehan Phinney Capitol Group.
The creation of this new business service is an exciting opportunity for CCNH to offers its clients additional services through the resources of the SPB+G law firm," said Bruce Berke, principal of CCNH and new member of Sheehan Phinney Capitol Group.
CCNH has been operating since 1989 and has provided government relations services to businesses and business organizations from New Hampshire and across the country.