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CCR2C-C Chemokine Receptor 2 (gene)
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The company's lead product candidate, cenicriviroc (CVC), is a first-in-class immunomodulator and dual inhibitor of CCR2 and CCR5 being evaluated for the treatment of non-alcoholic steatohepatitis (NASH).
Macrophages without CCR2 originate in the heart; those with CCR2 come from the bone marrow, the research showed.
To confirm the key role of CCR2 signaling in development of the observed movement-provoked pain behavior after surgery, the researchers administered a CCR2 receptor-blocker to normal mice at nine weeks after surgery and found that this reversed the decrease in distance traveled, that is, movement-provoked pain behavior.
CCR2 The receptors encoded by this gene mediate the agonist-dependent calcium mobilization and the inhibition of adenylyl cyclase.
IL-13-induced chemokine responses in the lung: role of CCR2 in the pathogenesis of IL-13-induced inflammation and remodeling.
CCR2 V64I (G/A), MCP-1 -2518 A/G, SDF-1[alpha] 3'UTR G/A genotypes were identified using polymerase chain reaction based restriction fragment length polymorphisms (PCR-RFLP) as described elsewhere (19-21).
Contrasting influence of CCR2 and CCR5 variants on HIV infection and disease progression.
Other subjects covered are smoking and chemokine levels, the role of chemokine MCP-1 and its receptor CCR2 in neuropathic pain, the importance of the CCLR27-CCR10 chemokine ligand-receptor interaction in melanoma, and novel aspects of amniotic fluid examination for chorioamnionitis.
for the Development and Commercialization of CCR2 Antagonists
The United States of America as represented by the Department of Health and Human Services (Washington, DC) has patented a CCR2 deletion mutant, designated "CCR2-64I.
Several chemokine receptor molecules have also been studied including the CCR2 and CXCR4 molecules.
Researchers here at the National Cancer Institute found that a mutation on the CCR2 gene can delay the progression of AIDS for 2-4 years from time of infection with the HIV-1 virus, according to a report in Science 1997;277:959-965.