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CCR5C-C Chemokine Receptor 5 (gene)
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Chemokine receptor CCR5 promotes leukocyte trafficking to the brain and survival in West Nile virus infection.
The CCR5 inhibitors are compelling candidates as an alternative because these drugs are not being used for treatment in, for example, Africa," Moore said.
CCR5 is important in guiding trafficking of inflammatory lymphocytes into the CNS, where they can help clear the WNV.
More recently, CCR5 variant allele has been reported to confer significant risk for gallbladder cancer (Srivastava et al.
Trofile is a patient selection co-receptor tropism assay that determines whether a patient is infected with a strain of HIV that uses the CCR5 co-receptor, the CXCR4 co-receptor, or a combination of CCR5 and CXCR4 to enter cells.
Washington, June 7 ( ANI ): The HIV drugs known as CCR5 antagonists may also help prevent aggressive breast cancers from spreading to other sites in the body by metastasis, a new study has revealed.
The others receptors that it uses are CCR5 and CXCR4, with CCR5 being the most common.
uninfected cells by blocking its predominant entry route, the CCR5 co-
We expect that CCR5 antagonists, like maraviroc, will become critically important new treatment options for patients who are resistant or intolerant to their current HIV/AIDS therapies.
The CCR5 mutation showed up in more than 4 percent of the West Nile patients but in only 1 percent of 1,318 healthy blood donors used as a comparison group, the researchers report in the Jan.
CCR5 is a protein on the surface of human cells that most HIV uses to help it enter the cell (some HIV uses a different protein instead, usually CXCR4).
Virus isolates recovered from infected individuals in the early stages of disease utilize chemokine receptor CCR5 (R5) exclusively as a coreceptor for cellular infection and do not induce syncitium formation in transformed T-cell lines in vitro (non-syncitium inducing or NSI).