Expression of CCR7
in multiple sclerosis: implications for CNS immunity.
In this investigation, gene expression of the chemokine receptors CCR7
and CXCR4 was upregulated after application of both sensitizers.
Moreover, the expression of CCR7
and CXCR4 on circulating T-cells, the increase of CXCL12 plasma concentration and the production of CCL19 and/or CCL21 mRNA in lymph nodes also suggest homing into secondary lymphoid organs.
In analyzing the data from the trial we sought to detect immune correlates by using multi-parametric flow cytometry to identify 16 unique RCC antigen reactive CTL subsets based on the expression of the surface markers CD28, CD45RA, CD27 and CCR7
, present in blood draws collected prior to treatment with AGS-003 or sunitinib and after administration of five doses of AGS-003 in combination with sunitinib.
2a] K, PE conjugated; BD Biosciences); and chemokine receptors CCR7
(4B12, rat Ig[G.
It is now established that activated T cells express more CCR1 through CCR7
Gene expression changes in foam cells and the role of chemokine receptor CCR7
during atherosclerosis regression in ApoE-deficient mice.
Expression of FCER2 (32, 33), CD52 (34), FAIM3 (33), CCR7
(30), HLA-DRA (34), and BTG1 (29) has been associated with B-CLL.