25) The pDCs also require CCR7
to enter the lymph nodes via HEVs.
When the group genetically eliminated CCR7
from CD103 cells, this transport was greatly reduced, and tumors in mice lacking CCR7
grew significantly faster.
Chemokine receptor CCR7
expression predicts poor outcome in uveal melanoma and relates to liver metastasis whereas expression of CXCR4 is not of clinical relevance.
Expression of CCR7
in multiple sclerosis: implications for CNS immunity.
In this investigation, gene expression of the chemokine receptors CCR7
and CXCR4 was upregulated after application of both sensitizers.
El fenotipo clasico de las DC maduras incluye una expresion de alta densidad en la superficie de CD40, CD83, moleculas coestimuladoras (CD80 y CD86) y el receptor de quimiocinas CCR7
Moreover, the expression of CCR7
and CXCR4 on circulating T-cells, the increase of CXCL12 plasma concentration and the production of CCL19 and/or CCL21 mRNA in lymph nodes also suggest homing into secondary lymphoid organs.
To date, most chemokine receptors, such as CXCR4 and CXCR5 on T cells and B cells, have been shown to be induced by Gi in the classic pathway, while CCR7
and CXCR4 have been shown to be dependent on Gq pathways only on dendritic cells (DCs) .
has been detected in various immune cells and promotes cell migration toward CCL19 and CCL21, which are considered as inflammatory cytokines due to the fact that they appear in most chronically inflamed organs .
47),(68),(69) The interaction between chemokines produced in the interfollicullar region of the PPs and chemokine receptors, such as between CCL19 and CCR7
and between CCL20 and CCR6, plays an important role in the transport of dendritic cells to T cell zones.
It involves upregulation of the chemokine receptor CCR7
and chemoinvasion towards lymphatic vessels.
The characteristics of semi-mature DCs are high expression of co-stimulatory molecules and CCR7
, low excretion of cytokines, which have been related to immune tolerance and homeostasis.