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CCR8C-C Chemokine Receptor 8 (gene)
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61) Notably, malignant melanoma cells often express high levels of CCR8 and use CCL1-CCR8 to enter into the lymph node parenchyma, forming lymph node metastases.
This translocation creates NPM-ALK (Nucleophosphmin anaplastic lymphoma kinase) gene with transforming potential,7 while other mutations are also implicated like defective expression of TCR, CCR8, and CCR10.
Typically, CXCR3 and CCR5 are preferentially expressed on polarized Th1 cells, whereas CCR3, CCR4 and CCR8 have been associated with the Th2 phenotype.