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CCR8C-C Chemokine Receptor 8 (gene)
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2 containing MYC) and losses on 9p21 (containing p16/CDKN2A, tumor suppressor gene) (336,340,341); concurrent gene expression analysis showed higher expression of skin-homing chemokine receptors CCR10 and CCR8 on C-ALCL, which potentially explains the lower tendency of C-ALCL to disseminate.
In addition, more mRNA for CCR8 could be detected after application of Ni[SO.
However, Mo-DCs also express CCR8, indicating--like CCR7--its role in DC migration from skin to the lymph node (14).