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CCR9 |
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ChemoCentryx's lead compound, Traficet-EN, a specific CCR9 antagonist, is currently in a multi-national clinical trial, called PROTECT-1, in patients with moderate-to-severe Crohn's disease. The chemokine receptor CCR9 appears to be selectively involved in the migration of T cells to the gut and likely will meet future drug development. p-53-dependent benzene-induced decrease or increase Decrease Adcy6, ApoE, AQ1, B cell antigen receptor, Cam III, CCR9, E2F1, WT: decreased FATP4, Fscn1, GPCR (EB11), Ig kappa light chain, IgA, IgH, p53-KO: unchanged mur42, Pdk1, PPT-B, Prkm1, TP, TRBF1 Increase Adipose fatty acid binding protein, Adh-3, caspase-11, cyclin G1, WT: increased CYP7B1, EGFB-3, emp-1, FKBP23, c-fos, Hox-4. |
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