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CCTG |
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Myotonic dystrophy type 2 (DM2) is caused by an expansion of a CCTG repeat in intron 1 of the gene ZNF9, which encodes zinc finger protein 9 on chromosome 3q. For XRCC3 genotyping,the XRCC3 Thr241 Met polymorphism, a T [right arrow] C transition in exon 7 (position 18067) was determined using the following primers: sense, 5 '-G CCTG GTG GTCATCGACTC- 3'; antisense, 5 '-ACAGGGCTCTGGAAGGCACTGCTCAGCTCACGCACC-3'. The CCTG 575 study failed to show a benefit from phenotyping in guiding the selection of a salvage regimen, except in the subgroup of patients with virus resistant to more than 3 protease inhibitors at baseline. |
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