CD40


Also found in: Medical.
AcronymDefinition
CD40Cluster of Differentiation 40 (glycoprotein)
References in periodicals archive ?
HSYA lessened GEE-induced platelet activation, as suggested by the observed decrease in platelet aggregation; reduction in plasma levels of sCD40L; decreased expression of CD40, MMP-9, ICAM-1, and VCAM-1 in lung tissue; and decreased expression of CD61 and CD40L in platelets.
Taking into account the importance of IL-18 and CD40 in T cell activation and important role of t-cell activation in kidney allograft rejection, the aim of the present study was to investigate the association of single nucleotide polymorphisms (SNP) in the genes of these two molecules with allograft rejection in kidney transplant recipients.
The panel of antibodies (with associated function) we used was CD23 [low-affinity immunoglobulin (Ig) E receptor], Fee receptor-1 (FceRl; high-affinity IgE receptor), CD80, CD86, CD40, HIA-DR (a major histocompatibility complex class II; antigen presentation), CDla (antigen presentation), CD1 lb/CR3, CD54/intercellular adhesion molecule-1 (1CAM-1; complement-mediated phagocytosis, cell migration; immune complex binding), CD14, CD16, and CD64 (lipopoly-saccharide; inflammation; innate immunity).
Notably elevation of soluble CD40 ligand identified the subgroup of patients likely to benefit from anti-platelet treatment with abciximab35.
CD40 ligand blocks apoptosis induced by tumor necrosis factor alpha, glucocorticoids, and etoposide in osteoblasts and the osteocyte-like cell line murine long bone osteocyte-Y4.
Recombinant human CD40 ligand Stimulates B cell proliferation and immunglobulin E secretion.
All the main cell types involved in atherosclerosis, including ECs, macrophages, T cells, SMCs, and platelets, express this proinflammatory cytokine as well as its receptor, CD40 (46).
The virus, which is injected into the body, attaches itself to a molecule called CD40 on the cell's surface, which kills the cancer cell.
Dr Daniel Palmer, from Birmingham University, said the technique targets a molecule called CD40, which normally plays a key role in activating the immune system, but which is also present in common tumours including breast, liver and skin cancers.
This CD40 antagonistic mAb was discovered by Kirin and shows strong immunosuppressive activity in preclinical studies.
DCs were generated by culturing monocytes with granulocyte macrophagecolony stimulating factor (GM-CSF) and interleukin (IL-4) and activated by additional culture with tumor necrosis factor and CD40 ligand.