RAPID3 is correlated significantly with other composite indices, such as DAS28 and CDAI
Worsening was defined as an increase in CDAI
of at least 70 points from the qualifying baseline score.
The primary outcome criterion was the number of patients in each group in remission [defined as a CDAI
score <150 points (23)] at week 16, with total steroid withdrawal.
Clinical remission is defined as a CDAI
score of less than 150 at three consecutive time points of 9, 12 and 15 weeks after initiation of treatment.
6 mg/kg achieved clinical remission at week 8, as defined by a CDAI
score of less than 150 points, compared with 20 percent of patients receiving placebo (P = 0.
1, and a CDAI
of 38, all indicating high activity, although there are no swollen joints and DOCGL is 0.
When outpatient infections (2,223 of the total 2,282) alone were considered, researchers found that for all patients with CDAI
scores less than 10 of a possible 76 (corresponding to the mildest class of disease), there was a 14% increase in outpatient infections for each 5-point increase in score, after the researchers controlled for covariates including body mass index, smoking, and disease duration (incidence rate ratio, 1.
b) Wormwood showed a significant reduction of TNF-alpha, clinical improvement in CDAI
scores and improvement in mood in the active treatment group.
As primary outcome, changes of the CDAI
values between the status of enrolment and end of therapy were chosen.
Osiris reports that in patients who failed using currently available drugs for Chrohn's disease, there was a statistically significant reduction in the mean CDAI
score with 105 points by day 28.
The primary efficacy endpoint is a significant reduction in CDAI
(Crohn's Disease Activity Index), a standardized index originally developed as a monitoring tool in the National Cooperative Crohn's Disease Study.
Routine laboratory data and numerical values for pain, stool characteristics, well-being, and other factors were used to calculate the CDAI
and the UC activity index (5).