CDC42 is also a small GTPase that belongs to the Rho family which has multiple functions in regulating both the microtubule and actin cytoskeleton (Etienne-Manneville and Hall, 2003).
Asymmetric positioning and organization of the meiotic spindle of mouse oocytes requires CDC42 function.
4] Human genes: TBX3, T-box 3, MGC15523, solute carrier family 38, member 10; SOX14, (sex determining region Y)-box 14; CDC42EP1, CDC42 effector protein (Rho GTPase binding) 1; SPN, sialophorin; ALB, albumin; APOE, apolipoprotein E; RNASEP, ribonuclease P; SRY, sex determining region Y; UTY, ubiquitously transcribed tetratricopeptide repeat gene, Y-linked; MGC15523, solute carrier family 38, member 10; LDHA, lactate dehydrogenase A; POP5, processing of precursor 5, ribonuclease P/MRP subunit; RASSF1A, Ras association (RalGDS/ AF-6) domain family member 1.
10,14) on the basis of multilocus sequencing with ITS, CDC42
, BT2, and ACT1.
The validated target genes for miR-224 are AP15 (apoptosis inhibitor 5) (21), AP2M1 (adaptor-related protein complex 2, mu 1 subunit) (33), CDC42
[cell division cycle 42 (GTP binding protein, 25 kDa)], CXCR4 [chemokine (C-X-C motif) receptor 4] (30), SMAD4 (SMAD family member 4) (34), SMAD5 (SMAD family member 5) (17), SLMAP (sarcolemma-associated protein) (17), H3.
PAK is a family of serine/threonine protein kinases that are activated by RAS-related G proteins of 21 kDa (p21) called RAC and CDC42
Intestine Ensembl Gene ID Gene Symbol Gene Description ENSSSCG00000002523 CDC42BP B CDC42 binding protein kinase beta (DMPK-like) [Source :HGNC Symbol;Acc:1738] ENSSSCG00000019556 7SK.