Many genes whose expression is regulated by E2F family transcription factors, including CDK2, CCNE1, CDC6, CDC2, MCM2, were significantly down-regulated at 24 hr post-IR.
Pattern 8 was composed of 901 genes that were repressed moderately at 6 hr but highly repressed at 24 hr, including many genes whose products participate in various DNA metabolic events during the cell division cycle, such as ASK, CCNA2, CCNB1, CCNB2, CDK2, CDC2, CDC6, CDC45L, CDC7L, MCMs, RFC subunits, and TOP2A (Mendez and Stillman 2000; Stillman 1996).
1]/S transition and initiation of DNA replication, including CCNE, CDK2, CDC6, CDC45, CDC7, RFC subunits, and MCM family members, were down-regulated at 6 and 24 hr post-IR as an expected consequence of the p53-dependent induction of CDKN1A (p21Wafl) to enforce the [G.
We found that genes required for the replication of chromosomal DNA (PCNA, FEN1, CDC6, MCM2, MCM3, MCM4, MCM5, ORC1, ORC6, RRM1, RRM2) and genes required for postreplicative phases of the cell division cycle (e.
cerevisiae) PCNA 101065_at proliferating cell nuclear antigen MCM2 93112_at mini chromosome maintenance deficient 2 CDC6 103821_at cell division cycle 6 homolog (S.