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CDDP |
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Further studies, however, have provided mechanistic evidence for CDDP biotransformation leading to oxidative stress along with a cascade of redox-associated events. The data indicated that GX15-070 induced apoptosis in several types of hematological cancer cell lines, both as a single agent and in combination with other cancer drugs such as rituximab, proteasome inhibitors, other Bcl-2 inhibitors, and chemotherapy agents such as CDDP and doxorubicin. Patients received G17DT in combination with CDDP and 5-FU. |
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