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CDK8Cyclin-Dependent Kinase 8
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These changes included NRAS [neuroblastoma RAS viral (v-ras) oncogene homolog] and CDK8 (cyclin-dependent kinase 8) aberrations that were labeled as "informative" because they could be matched in the future to clinical trials with MEK, PI3K, or CDK inhibitors.
When further investigating macroH2A function in melanoma, the researchers found that it regulates CDK8, a known oncogene for colorectal cancer.
Scientists think the gene CDK8 plays a role in many varieties of colon cancer.