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CDKN2Cyclic AMP (Adenosine Monophosphate)-Dependent Kinase Number 2
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The SCLC1 gene is linked with risk for lung cancer, and the CDKN2 gene is linked to malignant melanoma.
There has also been much attention paid to another tumor suppressor gene, CDKN2, that codes for the cell cycle regulatory protein cyclindependent kinase-4 inhibitor (p16).
Indeed, several studies have indicated that in prostate cancer, in which expression of hCG[beta]-3, -5, or -8 does not occur on malignant transformation (6), DNA hypermethylation is a frequent mechanism leading to inactivation of key regulatory genes such as E-cadherin, [pi]-class glutathione S-transferase, the tumor suppressors CDKN2 and PTEN, and insulin-like growth factor-II [for a review, see Ref.