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CDKN2Cyclic AMP (Adenosine Monophosphate)-Dependent Kinase Number 2
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Indeed, several studies have indicated that in prostate cancer, in which expression of hCG[beta]-3, -5, or -8 does not occur on malignant transformation (6), DNA hypermethylation is a frequent mechanism leading to inactivation of key regulatory genes such as E-cadherin, [pi]-class glutathione S-transferase, the tumor suppressors CDKN2 and PTEN, and insulin-like growth factor-II [for a review, see Ref.
CDKN2 explains part of the clinical phenotype in Dutch familial atypical multiple-mole melanoma (FAMMM) syndrome families.
Deletion mapping of chromosome region 9p21-p22 surrounding the CDKN2 locus in melanoma.