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CDR2 |
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A mutation in Tac1p, a transcription factor regulating CDR1 and CDR2, is coupled with loss of heterozygosity at chromosome 5 to mediate antifungal resistance in Candida albicans. The claims granted to Connetics cover TCR peptides and functional derivatives encompassing the CDR2 as compositions of matter, formulations (including peptide cocktails) and methods of treatment for T-cell mediated diseases. |
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