A histopathological diagnosis of a CEOT with extraosseous involvement was made.
The CEOT usually presents as an asymptomatic slow-growing bony-hard swelling.
In the Asian population, the CEOT shows a predilection for the maxilla, whereas in the Western population it shows a higher mandibular prevalence.
The radiographic appearance of the CEOT is variable, depending on the stage of the development.
Five histological variants reported in the literature are as follows: 1) A CEOT with stromal cementum-like components, 2) a clear-cell CEOT, 3) CEOT-containing Langerhans cells, 4) a combined epithelial odontogenic tumor, and 5) a CEOT with myoepithelial cells.
The malignant transformation in the CEOT is indicated by high mitotic activity, increased nuclear pleomorphism, increased proliferative activity measured with the MIB-1 index, and vascular invasion.
CEOT affects the mandible twice as often as the maxilla, and it has a marked predilection for the premolar/molar/ramus area (82% of cases).
Two topographic variants of CEOT have been identified: intraosseous and extraosseous.
4) Although CEOT is a benign neoplasm, its biologic behavior is variable, ranging from very slight to moderately invasive.
5) The specific epithelial cell from which CEOT originates remains unclear.
The diagnosis of CEOT is based on histologic examination.
The treatment of CEOT has ranged from simple enucleation or curettage to radical and extensive resection, such as hemimandibulectomy or hemimaxillectomy.