CFLARCASP8 and FADD-Like Apoptosis Regulator (Caspase-8 gene, CASP-8; Fas-Associated Protein with Death Domain, FADD)
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Sequences for IMPDH1 and 2, 2 known pseudogenes, and CFLAR (CASP8 and FADD-like apoptosis regulator) were obtained from GenBank.
4] Human genes: IMPDHI and IMPDH2, inosine monophosphate dehydrogenase 1 and 2; CFLAR, CASPS and FADD-like apoptosis regulator; ALASI, [delta]-aminolevulinate synthase 1; B2M, [beta]2-microglobulin; G6PD, glucose-6-phosphate dehydrogenase; HPRTI, hypoxanthine phosphoribosyltransferase 1; and HMBS, hydroxymethylbilane synthase (formerly PBGD, porphobllinogen deaminase).
Thus, for biomarker discovery, to be certain that the gene of interest is not affected by PAXgene, we recommend validation directly from blood without PAXgene treatment, particularly if the identified candidate biomarkers include CFLAR (33) or other apoptosis genes.