The histopathological findings were similar in both control and treated rats, indicating that the administration of CHCR at all 3 dose levels did not result in any adverse toxicological effect on these organs.
Treatment with 5-ASA and CHCR significantly lowered mRNA expression for cytokine IL-4 (table 2).
Cytokine levels after the treatment with standard drug and CHCR decreased when compared to the levels in the rats treated with DNBS alone (table 2).
Treatment with 5-ASA and CHCR prevented this target from modulating the progression of colitis (table 2).
Significant upregulation of IFN-[gamma] mRNA expressions in the DNBS model group, which was attenuated by 5-ASA and CHCR as seen by their levels of their transcripts, seems favorable (table 2).
There was also a significant reduction in the expression of this cytokine, which may be explained by the antioxidant effects of CHCR and the downregulation of the transcription of IL-4 mRNA in the treated groups.
CHCR treatment modulated IL-6 cytokine mRNA expression due to its cytoprotective, antiapoptotic, and anti-inflammatory effects in the experimentally induced IBD model.
26) 5-ASA and CHCR treatments prevented the colon injury caused by IL-12.