A pharmacodynamic biomarker could be an important contribution to our clinical development efforts, and we look forward to working with KineMed and CHDI
to evaluate KineMed's biomarker platform in our Huntington's disease program," said Frank Bennett, Ph.
and its collaborators have developed a unique series of 20 ES cell lines from genetically modified mouse models that mimic aspects of Huntington's disease.
is dedicated to researching therapies that could help Huntington's disease patients and our team looks forward to the collaboration with Samaritan.
Over time, CHDI
will be reimbursed for its support of Isis' program out of milestone payments received by Isis.
Following the successful start-up of their PPDI business, Du Pont is soon expected to bring CHDI
George Yohrling, PhD, Director, Target Assessment at CHDI
added, "This second phase of our collaboration with Galenea will focus on understanding whether there is a polyglutamine-length dependency to the observed synaptic alterations and on building a broad HD drug-discovery platform through the application of these novel findings.
More information about CHDI
can be found at http://www.
As part of the collaboration CHDI
will conduct pre-clinical studies on a Lundbeck investigative compound.
Evotec has long-term discovery alliances with partners including Bayer, Boehringer Ingelheim, CHDI
, Genentech, Janssen Pharmaceuticals, MedImmune/AstraZeneca and Ono Pharmaceutical.
The application of KineMed's technology will provide us with unique insights into central nervous system disease pathophysiology," said Seung Kwak, PhD, Director, Target Biology at CHDI
and supported by CHDI
- demonstrate that a small interfering RNA (siRNA) targeting the huntingtin gene, when administered by intrastriatal infusion with convection-enhanced delivery (CED), results in widespread distribution of the siRNA and significant silencing of the huntingtin mRNA throughout the striatum.
CAMD Members: Abbott, Alliance for Aging Research, Alzheimer's Association, Alzheimer's Foundation of America, AstraZeneca Pharmaceuticals LP, Bristol-Myers Squibb Company, CHDI
Foundation Inc, Eli Lilly and Company, F.