CIN1Cervical Intraepithelial Neoplasia 1 (abnormal cervical cell growth)
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This trial also demonstrated virological clearance of HPV 16 or 18 from the cervix in conjunction with histopathological regression of cervical dysplasia to CIN1 or no disease, a secondary endpoint of the trial, in 43 of 107 (40.
Clearly, the placebo effect was very large in this group, and this is expected in young women who have CIN1 and CIN2.
Data source: A randomized double-blind phase 2b trial of HAL photodynamic therapy in 262 patients with CIN1 or CIN2.
Pap smears were reported according to the Bethesda classification, (8) which allows additional descriptors of CIN1, 2 and 3.
All Pap smears that were normal (CIN2 or less when the original histology was CIN3; or CIN1 when the original histology was CIN2) were classified as 'lesser grade of disease'.
In the per protocol analysis, CIN2/3 resolved to CIN1 or no disease in 53 of 107 (49.
Site Telepathology 1 Cervix (biopsy) Undifferentiated carcinoma 2 Cervix (biopsy) Invasive SCC G3 (necrotic biopsy) 3 Cervix (biopsy) CIN3 4 Cervix (biopsy) In situ SCC 5 Cervix (biopsy) Condyloma 6 Cervix (biopsy) Condyloma 7 Cervix (biopsy) Condyloma 8 Cervix (biopsy) CIN1 + HPV 9 Cervix (biopsy) CIN1 + HPV 10 Cervix (biopsy) CIN1 + HPV 11 Cervix (biopsy) CIN2 + HPV 12 Cervix (cone) CIN3 + HPV 13 Vulva (biopsy) Condyloma 14 Skin Benign vascular neoplasia 15 Skin Granulation tissue 16 Skin Kaposi sarcoma 17 Skin Tyloma (callus) 18 Skin/soft tissues Elastofibroma 19 Skin Benign vascular neoplasia 20 Skin/soft tissues Lipoblastoma 21 Skin Suggestive of SCC (fragments) 22 Skin/soft tissues Low-grade sarcoma (leiomyosarcoma?
While the same 24-month conservative pathway should be followed for adolescent patients with biopsy-proven CIN1 or CIN 2 to allow for regression, the management options for adolescents and young women with a histologic diagnosis of CIN 2,3 include treatment using either excision or ablation of the T-zone depending on the adequacy of the colposcopic exam, or colposcopic and cytologic observation at 6-month intervals for 24 months, "as long as colposcopy results are normal and cytology is negative," said Dr.
For CIN1, I think we should be thinking twice," she said.
There are three levels of abnormalities - CIN1 (minor changes), CIN2 (moderate changes) and CIN3 (severe pre-cancerous changes).
Testing with the ProEx C biomarkers was negative in 7 of 8 cytological and histological specimens for which the biopsies revealed CIN1 or less.