CIN2Cervical Intraepithelial Neoplasia Grade 2
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Type 31 was the most common of the five additional HPV types in the 9-valent vaccine, followed by types 52 and 58, both of which are more frequent in CIN2 than CIN3.
We are aware of the cytological limitations in differentiating CIN2 and CIN3 but this aids in the triage of colposcopy clinic patients.
Infection of HPV 16/18 is estimated to account for more than 80 per cent of invasive cervical cancer including CIN3 and for 50 per cent of CIN2 lesions (52).
HPV DNA tests have excellent sensitivity (around 95%) for CIN2 or higher, but specificity is low (ranging in the 20s and 30s).
CIN2 is a much less reproducible and less valid diagnosis than CIN3: results from a histological review of population-based cervical samples.
In addition, Photocure will continue the discussion with FDA on classification of severity as recent clinical management guidelines recommend distinct treatment options for women with CIN2 and CIN3, particularly for the large group of women of child bearing potential.
Among patients with CIN2, nearly all of those treated with the highest dose of HAL and photodynamic therapy had a response at 3 months, compared with roughly half of their counterparts treated with placebo.
For histologic categories, significant revisions have been made for the management of CIN 1 and minor changes in CIN2,3 treatment guidelines.
Of the girls diagnosed with CIN2 or CIN3 disease, "nearly half [49%] were either lost to follow-up or noncompliant with treatment recommendations," she said.
Professor Peter Hillemanns, Head of Department of Gynecology and Obstetrics at the Medical University of Hannover, Germany will be presenting data on a placebo-controlled Phase IIb study of Cevira (hexaminolevulinate) photodynamic therapy in patients with CIN1 and CIN2 in the Advanced topics on colposcopy and treatment clinical session on Wednesday 6th November from 12.