The drug was well tolerated and showed evidence of CK2
is also known to be more common in cancers, which encourage cell growth.
The team developed new ways to manipulate the genome, and showed, by controlling expression, that the level of CK2
dictates the form of compensation through the phosphorylation of the clock protein FRQ.
The researchers tested two anti-CK2
drugs for their ability to stimulate the production of new brown fat in mice: a new small-molecule CK2
-blocker called silmitasertib (CX-4945), which is already in clinical trials as a cancer therapeutic; and a more precise next-generation antisense oligonucleotide (ASO) drug developed in collaboration with Isis Pharmaceuticals, which eliminates CK2
by blocking the RNA instructions cells use to produce it.
His team have also found that inhibition of CK2
is sufficient to prevent the effects of amyloid on transport.
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Cylene's leadership in exploiting CK2
pathways enables rational drug combinations for improved treatment outcomes against many cancer indications.
The tumor suppressor PTEN is phosphorylated by the protein kinase CK2
at its C terminus.
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is developing a second generation compound, building on the success of its first-in-class CK2
inhibitor, CX-4945, the company announced today.