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Secondary efficacy endpoints include evaluating the effect of MC-1 at 90 days following surgery on the same composite of events, measures of cardiac tissue damage as determined by CKMB and neurological function. The finding of lower death rates reinforces our view that minor differences in CKMB elevations between heparin with GPIIb/IIIa inhibitor and Angiomax-randomized groups at 30 days were inconsequential. The emergency physician currently has three diagnostic tools available at the time a patient presents to help assess the likelihood of ACS: 1) ECG, which measures electrical activity of the heart; 2) biomarkers of cardiac necrosis (troponin, CKMB, myoglobin), and 3) history and physical exam, to observe physical condition and identify cardiac risk factors such as obesity, smoking, family history, and diabetes. |
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