LCDR Jeff Post from NCHB1 deployed to CMPF and 2D FSSG FWD, Camp Patriot, Kuwait.
LT Terry Shaske from NCHB1 deployed CMPF and 2D FSSG FWD, Camp Patriot, Kuwait.
LCDR Mike Stiglitz from NCHB1 deployed to CMPF and 2D FSSG FWD, Camp Patriot, Kuwait.
LCDR Keith Weidenbach from NCHB1 deployed CMPF and 2D FSSG FWD, Camp Patriot, Kuwait.
To examine IS, IA, HA, and CMPF as potential inhibitors of furosemide serum binding, we measured the free fraction of furosemide at therapeutic concentration (6.
Then, the adjusted nonuremic pool was supplemented with IA, IS, HA, and CMPF to mimic the concentrations of these compounds in the uremic pool.
The inhibition behaviors of IS, IA, and HA were qualitatively similar to each other, whereas the effect of CMPF was much stronger.
4 shows the effects of oleate on the free fraction of furosemide in serum with or without CMPF.
The presence of oleate at concentrations up to double the albumin concentration had no significant effect on the increased free fraction of furosemide caused by CMPF binding.
To elucidate the role of CMPF on the complicated inhibition behaviors on furosemide binding observed in serum containing oleate, furosemide, and CMPF, we examined the influence of oleate on the binding of CMPF to serum protein.
Like oleate, qualitatively similar effects on the furosemide binding in the presence of CMPF were observed for both linoleate and stearate (Fig.
Among the endogenous solutes retained in uremia, IS, IA, HA, and CMPF are recognized as the major inhibitors of drug binding in serum in uremia.