CNF1Cytotoxic Necrotizing Factor-1
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The gene for CNF1 is chromosomally encoded and resides on a pathogenicity island in uropathogenic E.
Eukaryotic cells intoxicated with CNF1 exhibit membrane ruffling; the formation of focal adhesions and actin stress fibers; and DNA replication in the absence of cell division, a phenomenon that results in enlarged multinucleated cells (Figure 3).
Molecular localization of the Escherichia coli cytotoxic necrotizing factor CNF1 cell-binding and catalytic domains.