Several recent studies suggested that the diagnostic accuracy of CNH immunoassay methods depends not only on the peptide measured but also on the platform used (3, 7, 8).
3] Nonstandard abbreviations: CNH, cardiac natriuretic hormone; BNP, brain natriuretic peptide; NT-proBNP, N-terminal part of the propeptide of BNP; ECLIA, electrochemiluminescence immunoassay; NYHA, New York Heart Association; AUC, area under the curve; DOR, diagnostic odds ratio; sROC, summary ROC; CI, confidence interval.
Upon completion, the participant receives a certificate, a CNHS
pin and a sample press release.
invites nominees to submit a brief description of their submission or area of specialization for posting on its Web site: www.
Analyses were also conducted to assess differences in more specific outcome and process measures between TNHs and CNHs during the intervention period (i.
For example, when risk-adjusted hospitalization rates were found to differ between TNH and CNH patients from all facilities combined, we ranked TNHs and CNHs according to individual risk-adjusted) facility hospitalization rates to assess the extent to which the finding might be due to a few extreme facilities or represented a consistent pattern among all TNHs relative to CNHs.
Of course, the large number of pathophysiologic mechanisms affecting the CNH
system may make it difficult for clinicians to recognize the cause(s) of variations in that system's activity.
natriuresis) of infusion of CNHs [including ANP, BNP, and/or C-type natriuretic peptide (CNP)] are lower in patients or experimental animals with heart, liver, or renal failure (all sharing greatly increased plasma CNH concentrations) than those found by infusion of the same doses in control individuals or experimental animals (6-9).
Some studies have suggested that resistance to the biological effects of CNHs in heart failure may be attributable, at least in part, to variations in the ratio between biological and clearance-specific CNH receptors, related to an increase (up-regulation) in clearance receptors [the so-called type C receptors (NPR-C)] with a parallel decrease (down-regulation) in biological receptors [type A and B receptors (NPR-A and NPR-B)] (2, 4,10-13).
Although several reviews have recently been published on the biochemical characteristics and pathophysiologic relevance of CNHs
(1-7), a review specifically dedicated to evaluate in detail the diagnostic accuracy and prognostic relevance of the assay of CNHs
is not available in the literature.
include atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), and their related peptides, whereas other natriuretic peptides, such as C-type natriuretic peptide (i.
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